A NEW PATHOGENESIS OF ALBUMINURIA: ROLE OF TRANSCYTOSIS

A New Pathogenesis of Albuminuria: Role of Transcytosis

Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to Ski de fond - Enfant - Sous-Vetements basolateral membranes without disrupting cellular homeostasis.In kidney, macromolecular components in the serum, such as albumin, low-density lipoprotein and immunoglobulins, pas

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Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

AIMS/HYPOTHESIS:GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the ELDER FLOWERS pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets.In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia.Consequently, the aim of

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Geospatial clustering and modelling provide policy guidance to distribute funding for active TB case finding in Ethiopia

Tuberculosis (TB) exhibits considerable spatial heterogeneity, occurring in clusters that may act as hubs of community transmission.We evaluated the impact of an intervention targeting spatial TB hotspots in a rural region of Ethiopia.To evaluate the impact of targeted active case finding (ACF), we used a spatially structured mathematical model tha

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